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Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) dota and casein kinase 1a (CK1a)

SKU: 84471920373

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Description

and casein kinase 1a (CK1a)

NCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Phthalimidinoglutarimide-C3-O-PEG2-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-OH CAS Number n/a Related CAS Molecular Formula C20H26N2O6 Molecular Weight 390

Trametinib binds KRS-MEK and disrupts RAF-MEK

Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) dota and casein kinase 1a (CK1a)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived

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